Could Stage 4 Cancer Be Treated With Antiparasitic Medicine?

Stage 4 cancer is a critical phase of cancer where the tumor starts spreading to other parts of the body. At this stage, there are several different treatment options available depending on the type of cancer and where it’s located in your body. These treatments include chemotherapy, immunotherapy, radiation therapy and surgery. Each method works differently and has varying success rates.

A new study suggests that an antiparasitic medication could help fight advanced pancreatic cancer. The drug, called mebendazole, was given to mice with genetically engineered pancreatic cancer, and it stopped the growth of the tumors. The researchers also discovered that the drug reduced inflammation and prevented the spread of the tumors.

Mebendazole works by blocking a protein that controls cell growth. It also inhibits the production of glucose in cells, which blocks cancer cells from getting the energy they need to grow and survive. The research team, which included Gregory Riggins from Johns Hopkins University, published the results of their study in Oncotarget.

The research found that mebendazole interfered with tubulin polymerization and induced the degradation of cyclin B1 by anaphase-promoting complex (APC). This process stops cell division in the G2 phase of the cell cycle. It also caused p53 translocation to mitochondria and lowered expression of the glycolytic enzyme hexokinase II, which can promote cell proliferation.

In addition to preventing cell growth, mebendazole blocked ferroptosis, a cellular form of programmed cell death. This was caused by the inhibition of SLC7A11, which is involved in iron transport to lysosomes. It also led to the phosphorylation of MLKL, a receptor that triggers necroptosis.

However, the anthelmintic medicine was not effective at treating cancer in human patients. Health Canada lists fenbendazole as being for veterinary use only. The researchers hope that their findings will spur further studies into whether the drug can be used to treat other types of cancer.

Other research has shown that fenbendazole can enhance the cytotoxicity of 5-fluorouracil in resistant CRC cells. It can also inhibit cell invasiveness and increase the sensitivity of the cells to radiation. It can also reduce multidrug resistance in cancer cells.

Benzimidazole may also be used in combination with other cancer treatments to improve their effectiveness. Immunotherapy, which boosts your immune system to fight the cancer, may be a good choice for people with advanced-stage cancer. It is usually used in combination with radiation and chemotherapy.

If you have stage 4 cancer, it’s important to work closely with your healthcare provider to understand all of your treatment options. Your doctor can explain the risks and benefits of each method and help you make the best decision for your situation. Other treatment methods include removing the tumor, using radiation or surgery to shrink the tumor and prevent it from growing back, and hormone therapy. If you have a family history of certain types of cancer, you should talk to your doctor about genetic counseling and testing. This can help you know if you are at risk of developing the disease and be more proactive about getting checked. fenbendazole stage 4 cancer

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